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Updated: Jan 26, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Ruthenium(ii)/acetate catalyzed intermolecular dehydrogenative ortho C-H silylation of 2-aryl N-containing
Shun Liu1, Qiao Lin, Chunshu Liao
1School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, Guangdong Province, P.R. China. andonlee@163.com.
Abstract:
The first application of a RuHCl(CO)(PPh3)3-OAc catalytic system on the selective intermolecular mono C-H silylation of 2-aryl N-heterocycles using HSiEt3 as the silylating reagent has been described. This protocol features good functional group tolerance and high regioselectivity, and has potential for gram scale-up, which provides a convenient and practical pathway for the synthesis of versatile organosilane compounds. This catalytic system can also be applied to the silylation of challenging sp3 C-H bonds.
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