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Updated: Jan 26, 2026
10:01
An Efficient Strategy for Generating Tissue-specific Binary Transcription Systems in Drosophila by Genome Editing
Published on: September 19, 2018
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Growth arrest specific transcript 5 in tumorigenesis process: An update on the expression pattern and genomic
Soudeh Ghaforui-Fard1, Mohammad Taheri2
1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Summary
Growth arrest-specific 5 (GAS5), a long non-coding RNA, primarily acts as a tumor suppressor by inducing apoptosis. GAS5 also influences cancer risk and response to treatments, making it a potential therapeutic target.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Growth arrest-specific 5 (GAS5) is a long non-coding RNA (lncRNA) involved in gene expression regulation.
- GAS5 is predominantly recognized for its role in promoting apoptosis and suppressing tumor development.
Purpose of the Study:
- To review the multifaceted roles of GAS5 in cancer, including its function, association with cancer risk, and therapeutic potential.
Main Methods:
- Literature review of studies investigating GAS5 function in cancer.
- Analysis of in vitro and clinical data on GAS5 expression and its correlation with tumorigenesis.
- Examination of research on GAS5 genomic variants and their impact on cancer risk.
Main Results:
- While some studies show GAS5 upregulation in tumors, in vitro data largely support its tumor-suppressive function.
- Genomic variations in GAS5 have been linked to cancer susceptibility in certain populations.
- GAS5 modulates responses to anti-cancer therapies, as evidenced by in vitro and clinical findings.
Conclusions:
- GAS5 exhibits diverse roles in cancer, acting as a potential tumor suppressor.
- GAS5 is implicated in cancer risk and response to therapy.
- GAS5 represents a promising biomarker and therapeutic target for human cancers.
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