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Differential methylation in rare ophthalmic disorders: a systematic review protocol
Katie Kerr1, Helen McAneney1, Amy Jayne McKnight2
1Centre for Public Health, Queen's University Belfast, c/o Regional Genetics Centre, Level A, Tower Block, Belfast City Hospital, Belfast, BT9 7AB, Co. Antrim, UK.
Systematic Reviews
|April 12, 2019
Summary
This review explores differential methylation in rare eye diseases. Identifying these epigenomic markers could improve diagnosis and lead to new treatments for vision loss.
Area of Science:
- Ophthalmology
- Epigenetics
- Genomics
Background:
- Rare ophthalmic conditions cause significant vision loss, impacting independence and quality of life.
- Differential methylation, an epigenomic marker, is associated with various diseases, including ocular disorders.
- Understanding these epigenetic changes is crucial for rare eye diseases.
Purpose of the Study:
- To systematically review the literature on differential methylation in rare ophthalmic conditions.
- To determine the extent to which differential methylation has been identified and characterized in these disorders.
- To explore the potential diagnostic and therapeutic implications of these findings.
Main Methods:
- Systematic review of electronic databases (MEDLINE, EMBASE, PubMed, Cochrane).
- Inclusion of grey literature and reference list screening.
- Adherence to PRISMA guidelines for study selection and data extraction.
Main Results:
- This section is to be filled after the review is completed.
Conclusions:
- Differential methylation may serve as a biomarker for rare ophthalmic diseases.
- Identifying these markers could enhance diagnostic accuracy and speed.
- This research may uncover novel therapeutic targets for preventing or reversing vision loss.
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