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Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment

Xu Wu1, Wei Hu2, Lan Lu3

  • 1Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China.

Acta Pharmaceutica Sinica. B
|April 12, 2019
PubMed

Keywords:
1,25(OH)2D3, 1α,25-dihydroxyvitamin D31α,25-Dihydroxyvitamin D325(OH)D, 25-hydroxyvitamin DCAF, cancer-associated fibroblastCRC, colorectal cancerCSC, cancer stem cellCancer stem cellCancer-associated fibroblastDBP/GC, vitamin D-binding proteinESCC, esophageal squamous cell carcinomaGI, gastrointestinalNSCLC, non-small cell lung cancerPC, pancreatic adenocarcinomaPG, prostaglandinPSC, pancreatic stellate cellsTDEC, tumor derived endothelial cellTIC, tumor initiating cellTIL, tumor-infiltrating lymphocyteTME, tumor microenvironmentTumor microenvironmentTumor-derived endothelial cellTumor-infiltrating lymphocyteVDR, vitamin D receptorVDRE, VDR elementVEGF, vascular endothelial growth factorVitamin D

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