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Globular and Fibrous Proteins

Globular and Fibrous Proteins

Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...

Globular and Fibrous Proteins

Globular and Fibrous Proteins

Fibrous Proteins

Fibrous Proteins

Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...

Structural Joints: Fibrous Joints

Structural Joints: Fibrous Joints

Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...

Amino acids

Amino acids

Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible for...

Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

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Related Experiment Video

Updated: Jan 26, 2026

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

Published on: November 29, 2024

Bionic Poly(γ-Glutamic Acid) Electrospun Fibrous Scaffolds for Preventing Hypertrophic Scars.

Tingting Xu¹, Rong Yang¹, Xuebin Ma²

¹State Key Laboratory of Materials-Oriented Chemical Engineering, College of Food Science and Light Industry, Nanjing Tech University, Nanjing, 211816, China.

Advanced Healthcare Materials

|April 12, 2019

Summary

This study presents a novel bionic fibrous scaffold for scarless wound healing. The poly(γ-glutamic acid) scaffold, incorporating ginsenoside Rg3, promotes skin regeneration and reduces scarring.

Keywords:

bionic extracellular matrix hypertrophic scars poly(γ-glutamic acid) fibers wound healing

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In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding

Published on: May 1, 2020

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Last Updated: Jan 26, 2026

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

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Published on: November 29, 2024

Electrospun Fibrous Scaffolds of Polyglycerol-dodecanedioate for Engineering Neural Tissues From Mouse Embryonic Stem Cells

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In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding

Published on: May 1, 2020

Area of Science:

Biomaterials Science
Regenerative Medicine
Wound Healing

Background:

Hypertrophic scarring (HS) presents a significant challenge in wound management.
Existing bionic extracellular matrix (ECM) biomaterials for HS treatment often lack synergistic biological and application functions.
Bionic scar-inhibiting scaffolds offer a promising strategy for scarless skin regeneration.

Purpose of the Study:

To develop a versatile, ECM-inspired, poly(γ-glutamic acid)-based hydrogel fibrous scaffold.
To incorporate ginsenoside Rg3 (GS-Rg3) for enhanced tissue repair and wound therapy.
To evaluate the scaffold's efficacy in promoting scarless wound healing.

Main Methods:

Fabrication of photocrosslinkable hydrogel fibrous scaffolds using poly(γ-glutamic acid).
Incorporation of ginsenoside Rg3 (GS-Rg3) and decoration with adhesive peptides.
In vivo evaluation of scaffold performance in promoting wound healing and scar reduction.

Main Results:

The bionic fibrous scaffolds accelerated fibroblast growth and organized tissue formation.
Sustained release of GS-Rg3 promoted scarless wound healing by enhancing cell communication and skin regeneration.
Scaffolds led to decreased angiogenesis and collagen accumulation, indicating reduced scarring.

Conclusions:

ECM-inspired fibrous scaffolds offer a novel approach for accelerated wound healing.
The developed scaffold demonstrates potential for effective scarless skin regeneration and tissue repair.
This strategy provides new perspectives for advanced wound dressing applications.