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Related Concept Videos

Nucleic Acids02:43

Nucleic Acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
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The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Nucleic acids02:43

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
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Biosynthesis of Nucleic Acids01:28

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Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
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Nucleic Acid Structure01:25

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
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Nucleic Acids and Nucleotides01:20

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
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Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
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Nucleic Acid-Based Functional Nanomaterials as Advanced Cancer Therapeutics.

Ye Yuan1, Zi Gu2, Chi Yao1

  • 1Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300350, P. R. China.

Small (Weinheim an Der Bergstrasse, Germany)
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Nucleic acid-based functional nanomaterials (NAFN) offer advanced cancer therapy by enabling targeted drug delivery and stimuli-responsive release. This review highlights NAFN

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Oncology

Background:

  • Nucleic acid-based functional nanomaterials (NAFN) are emerging nanocarriers for cancer therapeutics.
  • NAFN exhibit unique properties like biocompatibility, biodegradability, and sequence programmability.
  • These properties facilitate effective loading, protection, and targeted delivery of therapeutic agents to tumors.

Purpose of the Study:

  • To review recent advancements in NAFN for cancer therapeutics.
  • To categorize NAFN applications in chemotherapy, immunotherapy, and gene therapy.
  • To discuss challenges and future directions for NAFN in biomedical applications.

Main Methods:

  • Literature review of recent progress in NAFN for cancer therapy.
  • Categorization of NAFN applications based on therapeutic approaches (chemo-, immuno-, gene-therapy).
  • Analysis of NAFN design strategies for addressing cancer therapy challenges.

Main Results:

  • NAFN demonstrate significant potential in chemo-, immuno-, and gene-therapy for cancer.
  • Rational design of NAFN enables targeted delivery and stimuli-responsive release of drugs.
  • NAFN's inherent biological functions and programmability are key to their therapeutic efficacy.

Conclusions:

  • NAFN represent a promising platform for developing advanced cancer therapeutics.
  • Further research is needed to overcome challenges and translate NAFN into practical clinical applications.
  • NAFN hold significant potential for future innovations in targeted cancer treatment and drug delivery.