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Related Experiment Video

Updated: May 19, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Nanoscale Spatial Engineering of Ligands Using DNA Origami for Precise Modulation of Membrane Receptor Signaling.

Chao Zhang1, Jinyue Fan1, Yanfei Guo2

  • 1Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, P. R. China.

Angewandte Chemie (International Ed. in English)
|May 17, 2026
PubMed
Summary

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DNA origami precisely controls ligand arrangement on cell surfaces, enhancing receptor signaling. This nanotech approach offers new ways to study and manipulate cellular functions for biological and therapeutic applications.

Area of Science:

  • Biotechnology
  • Nanotechnology
  • Cell Biology

Background:

  • Surface membrane receptor dimerization is crucial for cell signaling and function.
  • Ligand binding induces receptor aggregation, but precise spatial control is key for signaling fidelity.

Purpose of the Study:

  • To review methods for engineering ligand spatial arrangement using DNA origami.
  • To highlight DNA origami's advantages in controlling ligand parameters for receptor modulation.
  • To discuss applications and future directions in nanoscale ligand arrangement.

Main Methods:

  • Utilizing DNA origami's programmability and spatial addressability for nanostructure design.
  • Engineering precise control over ligand distance, valence, configuration, and stoichiometry.
Keywords:
DNA origamiligand spatial engineeringmembrane receptor signalingnanoscale spatial arrangementreceptor dimerization/multimerization

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Last Updated: May 19, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

  • Reviewing existing literature on DNA origami applications in membrane receptor signaling.

    • Main Results:

    • DNA origami enables fine-tuned control over ligand spatial arrangement at the nanoscale.
    • This precise control facilitates targeted modulation of surface membrane receptor signaling.
    • Demonstrated applications showcase the potential for user-defined biological investigations.

    Conclusions:

    • DNA origami is a powerful tool for precisely engineering ligand spatial arrangements.
    • This technology offers significant potential for modulating membrane receptor signaling in biological and therapeutic contexts.
    • Further research is needed to overcome challenges and fully realize the potential of nanoscale ligand engineering.