Related Experiment Video

Updated: Jan 26, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

597

Glomerular expression of matrix metalloproteinases in systemic lupus erythematosus in association with activity index

Konstantinos N Adamidis1, Maria-Emmanouela Kopaka2, Constantina Petraki2

  • 1a Private Hemodialysis Unit , "Bionephros" , Athens , Greece.

Renal Failure
|April 12, 2019
PubMed
Abstract

Insights

Matrix metalloproteinase (MMP) expression is elevated in lupus nephritis (LN) kidney biopsies, correlating with disease activity and renal dysfunction. Increased MMPs indicate a more severe inflammatory response in lupus nephritis patients.

Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus.
  • Matrix metalloproteinases (MMPs) are implicated in tissue remodeling and inflammation.
  • Understanding MMPs' role in LN is crucial for assessing disease activity and prognosis.

Purpose of the Study:

  • To investigate the expression of MMP-1, MMP-2, MMP-3, MMP-9, and TIMP-1 in kidney biopsies of LN patients.
  • To explore the relationship between MMP expression, disease activity index, and renal function in LN.

Main Methods:

  • Immunohistochemistry was used to detect MMPs and TIMP-1 in 58 LN kidney biopsies and 8 normal kidney tissues.
  • Clinical data from 36 LN patients were analyzed to correlate MMP expression with renal function and activity markers.

Main Results:

  • Increased expression of MMP-1, MMP-2, and MMP-3 was observed in LN glomeruli.
  • MMP expression significantly correlated with higher activity index scores and poorer renal function (p < .001).
  • Specific correlations were found between MMP-1 and leukocyte influx, MMP-3 and glomerular hypercellularity, and MMP-2 and fibrinoid necrosis/crescents.

Conclusions:

  • MMP expression is upregulated in the renal biopsies of LN patients.
  • Elevated MMP levels are directly associated with a heightened inflammatory response in LN.
  • Increased MMP expression correlates with greater disease activity and more severe renal dysfunction in lupus nephritis.
Keywords:
Lupus nephritisMMPmatrix metalloproteinases

More Related Videos

Detection of Functional Matrix Metalloproteinases by Zymography09:30

Detection of Functional Matrix Metalloproteinases by Zymography

Published on: November 8, 2010

84.9K
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

18.6K

Related Concept Videos

Renal Drug Excretion: Glomerular Filtration01:02

Renal Drug Excretion: Glomerular Filtration

The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
1.2K
Drug Elimination by Renal Route: Glomerular Filtration01:17

Drug Elimination by Renal Route: Glomerular Filtration

The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production takes place. A nephron has two main components: a renal corpuscle and a renal tubule. Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent...
7.0K
Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration01:29

Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration

The kidneys are vital organs responsible for regulating blood filtration, waste excretion, and fluid balance, all of which are crucial for maintaining homeostasis. Renal physiology examines renal blood flow, glomerular filtration, and urine formation, ensuring the body’s internal environment remains stable.Renal Blood FlowThe kidneys receive about 20-25% of the cardiac output, typically around 1200 mL of blood per minute in an average adult. Blood flows into the kidneys through the renal...
845
Transfer Function in Control Systems01:21

Transfer Function in Control Systems

The transfer function is a fundamental concept in the analysis and design of linear time-invariant (LTI) systems. It offers a concise way to understand how a system responds to different inputs in the frequency domain. It serves as a bridge between the time-domain differential equations that describe system dynamics and the frequency-domain representation that facilitates easier manipulation and analysis.
To derive the transfer function, consider a general nth-order linear time-invariant...
1.5K
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
6.9K
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
403