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Updated: Jan 26, 2026

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Contractile and hemodynamic forces coordinate Notch1b-mediated outflow tract valve formation

Jeffrey J Hsu1, Vijay Vedula2, Kyung In Baek3

  • 1Division of Cardiology, Department of Medicine, UCLA, Los Angeles, California, USA.

JCI Insight
|April 12, 2019
PubMed
Summary

Myocardial contractility is crucial for heart valve development, driving endothelial-to-mesenchymal transition (EndoMT) via Notch1b signaling. Increased wall shear stress (WSS) promotes valve growth, while reduced contractility halts it.

Keywords:
CardiologyCardiovascular diseaseDevelopmentEmbryonic development

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