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Histo-Blood Group Antigens in Children with Symptomatic Rotavirus Infection

Raúl Pérez-Ortín1, Susana Vila-Vicent2, Noelia Carmona-Vicente3

  • 1Department of Microbiology, School of Medicine, University of Valencia and Clinical Microbiology Service, Hospital Clínico Universitario de Valencia, Instituto de Investigación INCLIVA, 46010 Valencia, Spain. raul.perez@clinicalapau.es.

Viruses
|April 13, 2019
PubMed

Insights

Histo-blood group antigens (HBGAs) influence rotavirus gastroenteritis susceptibility in children. Secretor-positive individuals and those with blood groups A or AB are more prone to symptomatic rotavirus P[8] infections.

Area of Science:

  • Virology
  • Immunology
  • Genetics

Background:

  • Group A rotaviruses are a leading cause of acute gastroenteritis in children globally.
  • Rotavirus genotype prevalence varies geographically and is associated with human histo-blood group antigens (HBGAs).

Purpose of the Study:

  • To investigate the association between HBGA profiles and rotavirus gastroenteritis in children in Valencia, Spain.
  • To determine the role of secretor status, ABO blood group, and Lewis antigens in rotavirus infection susceptibility.

Main Methods:

  • Collected stool and saliva samples from 133 children with rotavirus infection (2013-2015).
  • Determined infecting rotavirus genotypes and HBGA phenotypes (secretor status, ABO, Lewis antigens).
  • Compared patient data with control groups and blood donor data.

Main Results:

  • Rotavirus G9P[8] was the most common strain (49.6%), followed by G1P[8] (20.3%) and G12P[8] (14.3%).
  • Infected children were predominantly secretor-positive (99%) and Lewis b positive (91.7%).
  • Children with blood group A and AB showed significantly higher susceptibility to rotavirus gastroenteritis compared to blood group O.

Conclusions:

  • A specific HBGA genetic background is linked to rotavirus P[8] susceptibility.
  • Symptomatic rotavirus P[8] infection is more frequent in secretor-positive (FUT2+) individuals.
  • No significant differences in susceptibility were found between rotavirus G genotypes based on HBGA profiles.

Keywords:
ABO group antigensLewisgastroenteritishisto-blood group antigens (HBGAs)rotavirussecretorsusceptibility

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