Related Experiment Video
Updated: Jan 26, 2026
09:43
Microfluidic Chip Fabrication and Method to Detect Influenza
Published on: March 26, 2013
15.5K
Novel Cost-Effective Microfluidic Chip Based on Hybrid Fabrication and Its Comprehensive Characterization
Sanja P Kojic1, Goran M Stojanovic2, Vasa Radonic3
1Faculty of Technical Sciences, University of Novi Sad, Trg Dositeja Obradovica 6, 21000 Novi Sad, Serbia. sanjakojic@uns.ac.rs.
Sensors (Basel, Switzerland)
|April 13, 2019
Summary
This study introduces a novel hybrid fabrication method for microfluidic chips, combining polyvinyl chloride (PVC) foils and Low Temperature Co-fired Ceramics (LTCC). The new chips demonstrate significantly higher flow rates and potential for low-cost, rapid production.
Area of Science:
- Microfluidics
- Materials Science
- Ceramics Engineering
Background:
- Microfluidic devices are crucial in medicine, biology, and chemistry.
- Advanced fabrication technologies are needed to overcome design challenges.
- Current methods face limitations in cost, speed, and performance.
Purpose of the Study:
- To present a novel hybrid fabrication technology for microfluidic chips.
- To combine polyvinyl chloride (PVC) foils with Low Temperature Co-fired Ceramics (LTCC) Ceram Tape.
- To evaluate the properties and performance of the fabricated microfluidic chips.
Main Methods:
- Hybrid fabrication using PVC foils and LTCC Ceram Tape.
- Combination of cost-effective xurography and laser micromachining.
- Optical, dielectric, and mechanical characterization (Young's modulus, hardness).
Main Results:
- Successful fabrication of microfluidic chips using the hybrid method.
- Determination of optical, dielectric, and mechanical properties.
- Microfluidic chips demonstrated 3000 times higher flow rates compared to standard xurography chips.
Conclusions:
- The proposed hybrid fabrication technology offers a promising approach for rapid, low-cost production of microfluidic chips.
- The fabricated chips exhibit high reliability, reproducibility, and enhanced performance.
- This method has significant potential for advancing microfluidic applications in various scientific fields.
Related Concept Videos
03:24Hybridization of Atomic Orbitals I
66.5K
The mathematical expression known as the wave function, ψ, contains information about each orbital and the wavelike properties of electrons in an isolated atom. When atoms are bound together in a molecule, the wave functions combine to produce new mathematical descriptions that have different shapes. This process of combining the wave functions for atomic orbitals is called hybridization and is mathematically accomplished by the linear combination of atomic orbitals. The new orbitals that...
66.5K
02:29Hybrid Zones
21.8K
Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.
21.8K
03:35Hybridization of Atomic Orbitals II
48.5K
sp3d and sp3d 2 Hybridization
48.5K
02:19Buffer Effectiveness
55.0K
Buffer solutions do not have an unlimited capacity to keep the pH relatively constant . Instead, the ability of a buffer solution to resist changes in pH relies on the presence of appreciable amounts of its conjugate weak acid-base pair. When enough strong acid or base is added to substantially lower the concentration of either member of the buffer pair, the buffering action within the solution is compromised.
The buffer capacity is the amount of acid or base that can be added to a given volume...
The buffer capacity is the amount of acid or base that can be added to a given volume...
55.0K
02:36Chromatin Immunoprecipitation- ChIP
12.2K
Chromatin immunoprecipitation, or ChIP, is an antibody-based technique used to identify sites on DNA that bind to transcription factors of interest or histone proteins. It also helps determine the type of histone modifications such as acetylation, phosphorylation, or methylation.
Types of ChIP
ChIP can be divided into two types - X-ChIP and N-ChIP. X-ChIP involves in vivo cross-linking of histones and regulatory proteins to DNA, fragmenting the DNA by sonication, and isolating the protein-DNA...
Types of ChIP
ChIP can be divided into two types - X-ChIP and N-ChIP. X-ChIP involves in vivo cross-linking of histones and regulatory proteins to DNA, fragmenting the DNA by sonication, and isolating the protein-DNA...
12.2K
03:26Framing Effects
7.9K
Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
7.9K