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Empowering Mesenchymal Stem Cells for Ocular Degenerative Disorders
Shirley Suet Lee Ding1, Suresh Kumar Subbiah2,3,4, Mohammed Safwan Ali Khan5,6
1Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. suetlee.ding@gmail.com.
International Journal of Molecular Sciences
|April 13, 2019
Summary
Mesenchymal stem cells (MSCs) show promise for eye diseases, but delivery challenges limit effectiveness. Enhancing MSCs with biomaterials, nanotechnology, and gene therapy can improve visual function and repair outcomes.
Area of Science:
- Ophthalmology
- Regenerative Medicine
- Biotechnology
Background:
- Multipotent mesenchymal stem cells (MSCs) are explored for treating various eye diseases, including age-related macular degeneration, glaucoma, and retinitis pigmentosa.
- Current MSC therapies face challenges with targeted delivery and cell survival, impacting therapeutic efficacy in ocular repair.
Purpose of the Study:
- To review strategies for enhancing mesenchymal stem cell (MSC) therapy outcomes in treating visual disorders.
- To explore the use of biomaterials, nanotechnology, and gene delivery to improve MSC function, differentiation, and ocular repair.
Main Methods:
- Review of current literature on MSC applications in ophthalmology.
- Analysis of biomaterial and nanotechnology approaches to augment MSCs.
- Discussion of gene delivery methods and therapeutic genes for ocular tissue modulation.
Main Results:
- Biomaterials and nanotechnology can enhance MSC function, differentiation, and survival for ocular applications.
- Gene delivery offers a means to modulate MSCs for improved ocular tissue repair and function.
- These strategies hold potential to overcome limitations in current MSC-based treatments for visual impairment.
Conclusions:
- Advanced strategies like biomaterials, nanotechnology, and gene therapy are crucial for optimizing MSC efficacy in treating eye diseases.
- Enhancing MSCs can improve cell precision, survivability, and ultimately, therapeutic outcomes for visual function restoration.
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