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Related Concept Videos

Extraction: Advanced Methods00:56

Extraction: Advanced Methods

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Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
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Reaction Mechanisms03:06

Reaction Mechanisms

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Chemical reactions often occur in a stepwise fashion, involving two or more distinct reactions taking place in a sequence. A balanced equation indicates the reacting species and the product species, but it reveals no details about how the reaction occurs at the molecular level. The reaction mechanism (or reaction path) provides details regarding the precise, step-by-step process by which a reaction occurs.
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
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Determining Order of Reaction02:53

Determining Order of Reaction

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Rate laws describe the relationship between the rate of a chemical reaction and the concentration of its reactants. In a rate law, the rate constant k and the reaction orders are determined experimentally by observing how the rate of reaction changes as the concentrations of the reactants are changed. A common experimental approach to the determination of rate laws is the method of initial rates. This method involves measuring reaction rates for multiple experimental trials carried out using...
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Reaction Rate02:53

Reaction Rate

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The rate of reaction is the change in the amount of a reactant or product per unit time. Reaction rates are therefore determined by measuring the time dependence of some property that can be related to reactant or product amounts. Rates of reactions that consume or produce gaseous substances, for example, are conveniently determined by measuring changes in volume or pressure.
The mathematical representation of the change in the concentration of reactants and products, over time, is the rate...
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Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups

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Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
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Reaction Quotient02:35

Reaction Quotient

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The status of a reversible reaction is conveniently assessed by evaluating its reaction quotient (Q). For a reversible reaction described by m A + n B ⇌ x C + y D, the reaction quotient is derived directly from the stoichiometry of the balanced equation as
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Related Experiment Video

Updated: Jan 26, 2026

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
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Recent Advances in Bioorthogonal Reactions.

Rebecca J B Schäfer1, Matthew R Aronoff2, Helma Wennemers3

  • 1Laboratorium für Organische Chemie, ETH Zurich, D-CHAB, Vladimir-Prelog-Weg 3, CH-8093 Zürich, SCS-DSM Award for best poster presentation in Chemical Biology.

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Summary

Chemoselective reactions in living systems enable cellular process studies and biomolecule ligations. Innovations in chemical biology offer new tools for understanding biological systems and molecular changes.

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Area of Science:

  • Chemical Biology
  • Biochemistry
  • Molecular Biology

Background:

  • Chemoselective reactions are crucial for manipulating biological systems.
  • These reactions have significantly impacted cellular process studies and biomolecule research.

Purpose of the Study:

  • To highlight recent innovations in chemoselective reactions for biological applications.
  • To showcase advancements in tools and resources for chemical biology research.

Main Methods:

  • Review of recent achievements in chemoselective reaction development.
  • Analysis of innovative applications in complex biological settings.

Main Results:

  • Demonstration of improved tools for studying cellular processes.
  • Advancements in ligating large biomolecules and imaging molecular changes.
  • New opportunities arising from creative chemical research.

Conclusions:

  • Innovation in chemical reactions continues to expand possibilities in chemical biology.
  • Chemoselective processes are vital for understanding biological systems at a molecular level.