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Impact of HIV-1 subtype and Korean Red Ginseng on AIDS progression: comparison of subtype B and subtype D

Young-Keol Cho1, Jung-Eun Kim1, Sun-Hee Lee2

  • 1Department of Microbiology, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Journal of Ginseng Research
|April 13, 2019
PubMed

Insights

HIV-1 subtype D infection accelerates disease progression and increases mortality risk compared to subtype B in Asian patients. Korean Red Ginseng may mitigate these effects, showing a greater impact in subtype D patients.

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Limited data exists on HIV-1 subtype D disease progression in Asian populations.
  • Understanding subtype-specific differences is crucial for effective HIV management.

Purpose of the Study:

  • To compare disease progression between HIV-1 subtypes D and B before combination antiretroviral therapy initiation.
  • To investigate the influence of Korean Red Ginseng (KRG) on disease progression in these subtypes.

Main Methods:

  • Retrospective analysis of CD4+ T cell annual decline (AD) in 163 patients (6 subtype D, 157 subtype B).
  • Comparison of AD based on HIV-1 subtype and KRG treatment status.
  • Analysis of mortality rates in relation to subtype and KRG use.

Main Results:

  • Subtype D infection showed significantly higher CD4+ T cell AD than subtype B.
  • KRG treatment was associated with lower AD, with a more pronounced effect in subtype D patients.
  • Mortality rates were significantly higher in subtype D-infected patients, irrespective of KRG treatment.

Conclusions:

  • HIV-1 subtype D is linked to a more rapid disease progression and a >2-fold increased risk of death compared to subtype B.
  • KRG treatment may offer a protective effect, particularly in subtype D infections.
  • Subtype D infection represents a more aggressive clinical course in the studied Asian cohort.
Abstract

Keywords:
AIDSDisease progressionHIV-1 subtype DKorean Red Ginsengnef gene

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