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Crizotinib in Chinese Patients with ROS1-Rearranged Advanced Non‒Small-Cell Lung Cancer in Routine Clinical Practice

Chang Liu1,2, Hui Yu1,2, Jianhua Chang1,2

  • 1Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.

Targeted Oncology
|April 13, 2019
PubMed
Abstract

Insights

Crizotinib demonstrated significant efficacy and good tolerability in Chinese patients with ROS1-positive non-small cell lung cancer (NSCLC). This real-world study confirms its effectiveness in managing advanced NSCLC with ROS1 rearrangements.

Area of Science:

  • Oncology
  • Pharmacology
  • Genetics

Background:

  • ROS1 rearrangements occur in 1-2% of non-small cell lung cancer (NSCLC) cases.
  • Crizotinib is a tyrosine kinase inhibitor (TKI) effective against ALK, MET, and ROS1.
  • Previous studies show crizotinib's antitumor activity in ROS1-positive advanced NSCLC.

Purpose of the Study:

  • To evaluate the real-world efficacy and safety of crizotinib in Chinese patients with advanced NSCLC and ROS1 rearrangement.
  • To analyze progression-free survival (PFS), overall survival (OS), objective response rate (ORR), and adverse events.

Main Methods:

  • Retrospective analysis of 35 Chinese patients with ROS1-positive NSCLC treated with crizotinib (250 mg twice daily).
  • Patients had histologically or cytologically confirmed locally advanced or metastatic NSCLC with ROS1 rearrangements.
  • ROS1 rearrangements were identified using fluorescence in situ hybridization, reverse transcriptase polymerase chain reaction, or next-generation sequencing.

Main Results:

  • The objective response rate (ORR) was 71.4% and the disease control rate (DCR) was 94.3%.
  • Median progression-free survival (PFS) was 11.0 months, and median overall survival (OS) was 41.0 months.
  • Common adverse events included elevated transaminases (54.3%), vision disorder (25.7%), and elevated creatinine (22.9%).

Conclusions:

  • Crizotinib is effective and well-tolerated in Chinese patients with ROS1-positive advanced NSCLC in real-world practice.
  • Treatment beyond progressive disease and local therapy after crizotinib failure were feasible and effective.
  • Diverse progression patterns and subsequent treatments were observed.

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