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Updated: Jan 26, 2026

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
Published on: January 26, 2024
A novel numerical model for protein sequences analysis based on spherical coordinates and multiple physicochemical
Jia-Feng Yu1,2, Ang Qu1, Hu-Cheng Tang1
1Shandong Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou, China.
Abstract:
How to characterize short protein sequences to make an effective connection to their functions is an unsolved problem. Here we propose to map the physicochemical properties of each amino acid onto unit spheres so that each protein sequence can be represented quantitatively. We demonstrate the usefulness of this representation by applying it to the prediction of cell penetrating peptides. We show that its combination with traditional composition features yields the best performance across different datasets, among several methods compared. For the convenience of users, a web server has been established for automatic calculations of the proposed features at http://biophy.dzu.edu.cn/SNumD/.
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