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Ventral attention-network effective connectivity predicts individual differences in adolescent depression.

Jie Liu1, Pengfei Xu2, Jingyuan Zhang3

  • 1College of Psychology and Sociology, Shenzhen University, Shenzhen, China; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Center for Brain Disorders and Cognitive Neuroscience, Shenzhen University, Shenzhen, China.

Journal of Affective Disorders
|April 13, 2019
PubMed
Summary

Adolescent depression is linked to stronger brain connectivity between the right ventrolateral prefrontal cortex (VLPFC) and left temporal-parietal junction (TPJ). This finding may help identify biomarkers for early depression detection.

Keywords:
Attention biasDepressionResting-state fMRIStochastic dynamic causal modellingVentral attention network

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Developmental Psychology

Background:

  • Negative attention bias is a key feature of depression, particularly in adolescents.
  • The ventral attention network (VAN), including VLPFC and TPJ, governs stimulus-driven attention.
  • Understanding VAN connectivity in adolescents is crucial for identifying early depression markers.

Purpose of the Study:

  • To investigate the neural correlates of attention bias in adolescents.
  • To examine the relationship between depression severity and effective connectivity within the VAN in healthy adolescents.

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) was used.
  • Stochastic dynamic modeling analyzed directional effective connectivity within the VAN.
  • 216 healthy adolescents participated in the study.

Main Results:

  • Higher self-reported depression scores correlated with stronger effective connectivity between the right VLPFC and left TPJ.
  • This enhanced connectivity within the VAN was observed in adolescents with greater depressive symptoms.

Conclusions:

  • Effective connectivity between right VLPFC and left TPJ may serve as a biomarker for bottom-up processing in adolescent depression.
  • This finding contributes to understanding the neural basis of depression vulnerability in adolescents.