Related Experiment Video
Updated: Jan 26, 2026

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients
Published on: September 9, 2020
Elevated plasma levels of soluble C-type lectin-like receptor 2 (CLEC2) in patients with thrombotic microangiopathy
Yoshiki Yamashita1, Kei Suzuki2, Takeshi Mastumoto3
1Department of Hematology and Oncology, Mie University Hospital and Mie University Graduate School of Medicine, Tsu, Japan.
Background:
Thrombotic microangiopathy (TMA) is caused by activated platelets. The plasma C-type lectin-like receptor 2 (CLEC2) levels in 58 patients with TMA were examined and compared with those in healthy volunteers and other diseases.
Materials And Methods:
The plasma levels of soluble platelet surface glycoprotein VI (GPVI) and CLEC2 were measured in patients with TMA.
Results:
Plasma CLEC2 levels in patients with DIC and TMA were significantly higher (p < 0.001) than those in thrombocytopenic patients with other hematological diseases, but no significant differences in the plasma CLEC2 levels were observed among patients with thrombotic thrombocytopenic purpura, hemolytic uremic syndrome (HUS), atypical HUS and other TMA. The plasma CLEC2 levels after the remission were significantly lower than those before treatment (p < 0.001). The plasma CLEC2 levels were poorly correlated with the levels of soluble GPVI in the plasma of patients with TMA. The plasma CLEC2 levels were not significantly differ between survivor and non-survivor in TMA patients, but were significantly higher in non-survivor in overall population (p < 0.001).
Conclusion:
The measurement of the plasma CLEC2 level is considered to be important for the diagnosis and evaluation of TMA.
Related Concept Videos
Types of Receptors: Internal Receptors
Similar to membrane-bound receptors, the binding of a ligand to the intracellular receptor of causes a conformational change in the...
Factors Affecting Solubility
Solubility Equilibria
The...
Types of Receptors: Cell Surface Receptors
Types of Hormones
Internal Receptors

