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Updated: Jan 26, 2026
07:06
Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta
Published on: April 3, 2017
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Mesenchymal stromal cells for ocular surface repair
Olla Al-Jaibaji1, Stephen Swioklo1, Che J Connon1
1a Institute of Genetic Medicine , Newcastle University, International Centre for Life , Newcastle upon Tyne , UK.
Expert Opinion on Biological Therapy
|April 14, 2019
Summary
Mesenchymal stem cells (MSCs) show promise for treating corneal damage by reducing opacity and vascularization. Their anti-inflammatory and immunomodulatory properties are key to promoting corneal healing and regeneration.
Area of Science:
- Ophthalmology
- Regenerative Medicine
- Stem Cell Biology
Background:
- Corneal damage leads to scarring and blindness, with limited effective treatments.
- Mesenchymal stem cells (MSCs) possess regenerative potential for ocular surface injuries.
- MSCs offer growth factor production, anti-inflammatory, and immunomodulatory capabilities.
Purpose of the Study:
- To review corneal disorder pathogenesis and MSCs' therapeutic potential.
- To investigate MSC mechanisms of action in corneal healing.
- To explore MSCs for treating and preventing corneal deterioration.
Main Methods:
- Review of over 25 animal studies on MSCs for corneal injury.
- Analysis of MSCs' common mechanisms of action.
- Evaluation of MSCs' impact on corneal wound healing parameters.
Main Results:
- MSCs modulate corneal wound healing by reducing opacity and vascularization.
- MSCs promote corneal re-epithelialization.
- MSC-derived anti-inflammatory and immunomodulatory factors are crucial for improved healing.
Conclusions:
- MSCs demonstrate significant potential in treating corneal damage.
- MSC therapy offers a promising avenue for regenerative ophthalmology.
- Targeting MSCs' therapeutic properties could advance corneal disease treatment.
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