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Related Experiment Video

Updated: Jan 26, 2026

Measuring the Time-Evolution of Nanoscale Materials with Stopped-Flow and Small-Angle Neutron Scattering
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Image-Based Flow Cytometry and Angle-Resolved Light Scattering to Define the Sickling Process.

Polat Goktas1,2, Ilya O Sukharevsky3, Sandra Larkin4

  • 1Department of Electrical and Electronics Engineering, Bilkent University, Ankara 06800, Turkey.

Cytometry. Part a : the Journal of the International Society for Analytical Cytology
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Summary

Sickle cell patients

Keywords:
HbS polymerizationcomputational flow cytometrylight scatteringprecision and personalized patient-oriented medicinered blood cellssickle cell disease

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Area of Science:

  • Hematology
  • Biophysics
  • Medical Diagnostics

Background:

  • Sickle cell disease is characterized by abnormal red blood cell (RBC) morphology.
  • Sickle hemoglobin (HbS) polymerization under low oxygen causes heterogeneous RBC shapes.
  • Understanding RBC morphological changes is crucial for managing sickle cell disease.

Purpose of the Study:

  • To quantitatively assess RBC morphological changes in sickle cell patients under varying oxygen tensions.
  • To establish an image-based flow cytometry method for dynamic RBC sickling analysis.
  • To provide insights into RBC shape dynamics and their relation to vaso-occlusive events.

Main Methods:

  • Utilizing angle-resolved light scattering with image-based flow cytometry.
  • Analyzing large populations of RBCs from sickle cell patients.
  • Characterizing RBCs using parameters like shape, size, and orientation.

Main Results:

  • Demonstrated heterogeneous RBC morphologies including discocytes, sickle cells, and abnormal shapes.
  • Provided statistically relevant, dynamic information on RBC sickling over time.
  • Established a reliable method for quantitative assessment of RBC shape changes.

Conclusions:

  • Angle-resolved light scattering and flow cytometry offer a powerful tool for studying RBC sickling.
  • This method aids in understanding disease progression and evaluating anti-sickling treatments.
  • Improved understanding can lead to better patient quality of life.