Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ion Channels01:19

Ion Channels

91.3K
The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
91.3K
Channel Rhodopsins01:11

Channel Rhodopsins

3.2K
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
3.2K
Non-gated Ion Channels01:24

Non-gated Ion Channels

8.1K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
8.1K
Channels of Non-Verbal Communication01:28

Channels of Non-Verbal Communication

400
Non-verbal communication plays a critical role in human interaction, influencing how individuals perceive emotions and psychological states. It operates through four primary channels: facial expressions, eye contact, body language, and touch. These non-verbal cues help convey meaning beyond spoken language and are often culturally influenced.Facial Expressions and Emotional RecognitionFacial expressions are among the most powerful and universal forms of non-verbal communication. Research has...
400
Uniform Depth Channel Flow01:27

Uniform Depth Channel Flow

549
Uniform depth channel flow keeps fluid depth consistent along channels such as irrigation canals. In natural channels, such as rivers, approximate uniform flow is often assumed. This condition occurs when the channel’s bottom slope matches the energy slope, balancing potential energy lost from gravity with head loss due to shear stress. This balance prevents depth changes along the channel length, resulting in a steady, uniform flow.Uniform flow in open channels with a constant cross-section...
549
G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

5.7K
GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Supraspinal Circuit Mechanisms Underlying Itch Processing.

CNS neuroscience & therapeutics·2026
Same author

Machine-intelligent multimodal algebot for intracavitary chemotherapy.

Nature nanotechnology·2026
Same author

Heritability Patterns of Protein-Coding Genes Expression: Insights From the Pig Genotype-Tissue Expression Project.

Animal genetics·2026
Same author

Galectin-3 Regulates Smooth Muscle Contraction and Blood Pressure by Modulating Ca<sub>V</sub>1.2 Channel Function.

Circulation·2026
Same author

LncRNA106907 enhances hepatic lipid metabolism via GPAM and is associated with laying performance in chickens.

Poultry science·2026
Same author

Artificial exosomes synergistically reshape sepsis immune homeostasis by modulating neutrophil fate and blocking PD-1/PD-L1.

Cell reports. Medicine·2026

Related Experiment Video

Updated: Jan 26, 2026

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
06:19

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches

Published on: June 16, 2023

3.8K

TRPM4 channel and cancer.

Yahui Gao1, Ping Liao2

  • 1Calcium Signalling Laboratory, National Neuroscience Institute, Singapore.

Cancer Letters
|April 14, 2019
PubMed
Summary

Transient Receptor Potential Melastatin 4 (TRPM4) channels are implicated in cancer. This review explores TRPM4

Keywords:
CalciumCancerInvasionIon channelsMigrationProliferation

More Related Videos

Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

12.4K
Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

9.9K

Related Experiment Videos

Last Updated: Jan 26, 2026

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
06:19

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches

Published on: June 16, 2023

3.8K
Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

12.4K
Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

9.9K

Area of Science:

  • Molecular Biology
  • Oncology
  • Ion Channel Physiology

Background:

  • The TRPM4 channel is recognized for its role in neurological and cardiac conditions.
  • Emerging research suggests TRPM4 involvement in specific cancers like prostate cancer and lymphoma.
  • TRPM4 expression may influence cancer cell migration and invasion, though mechanisms are unclear.

Purpose of the Study:

  • To review the expression of TRPM4 across various cancer types.
  • To summarize current knowledge regarding TRPM4's function in cancer.
  • To elucidate the potential mechanisms by which TRPM4 regulates calcium homeostasis in cancer cells.

Main Methods:

  • Literature review synthesizing existing research on TRPM4 in cancer.
  • Analysis of TRPM4 expression patterns in different malignancies.
  • Discussion of TRPM4's biophysical properties and their relevance to cancer cell behavior.

Main Results:

  • TRPM4 is expressed in several cancer types, potentially mediating cancer cell migration and invasion.
  • TRPM4 activation leads to sodium influx, membrane depolarization, and altered calcium homeostasis.
  • Disturbed calcium signaling is linked to cancer cell behaviors.

Conclusions:

  • Research on TRPM4 in cancer is in its nascent stages.
  • TRPM4 plays a role in regulating calcium homeostasis, crucial for cancer cell functions.
  • Targeting TRPM4 could offer a novel therapeutic strategy against cancer metastasis by modulating calcium signaling.