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HLA-D/DR expression on epithelial cells: the finger on the trigger?
Annals of the New York Academy of Sciences
|January 1, 1986
Summary
Epithelial human leukocyte antigen (HLA)-D/DR expression is linked to autoimmunity. These molecules on thyroid cells play a role in autoimmune disease initiation and progression.
Area of Science:
- Immunology
- Endocrinology
- Pathogenesis of Autoimmune Diseases
Background:
- Epithelial cells express human leukocyte antigen (HLA) class II molecules, specifically HLA-D/DR.
- The role of epithelial HLA-D/DR in autoimmunity, particularly in thyroid diseases, is under investigation.
Purpose of the Study:
- To investigate the association between epithelial HLA-D/DR expression and autoimmunity.
- To determine the role of HLA-D/DR on thyrocytes in presenting antigens and contributing to autoimmune pathogenesis.
Main Methods:
- Analysis of epithelial HLA-D/DR expression.
- Assessment of thyrocyte ability to present exogenous and autoantigens.
- Investigation of inducers of epithelial HLA-D/DR expression, including interferon-gamma (IFN-γ).
Main Results:
- A clear association was found between epithelial HLA-D/DR expression and autoimmunity.
- Thyrocytes expressing HLA class II molecules can present both exogenous antigens and autoantigens.
- Interferon-gamma (IFN-γ) can induce HLA-D/DR expression in thyroid epithelium, but other inducers are also suggested.
Conclusions:
- Epithelial HLA-D/DR expression is strongly associated with autoimmune diseases.
- These molecules on thyrocytes actively contribute to autoimmune pathogenesis.
- Epithelial class II expression likely plays a crucial role in both the initiation and propagation of autoimmune attacks.