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Published on: September 27, 2017
[Vemurafenib-induced radiation recall dermatitis]
A Greliak1, A Le Guern1, M Bataille1
1Service de dermatologie, faculté catholique de Lille, hôpital Saint-Vincent-de-Paul, 59000 Lille, France.
Introduction:
Radiation recall dermatitis is an uncommon inflammatory reaction of the skin appearing after several days to several years at the site of previous irradiation; it is precipitated by the use of triggering drugs, although rarely by BRAF or MEK inhibitors.
Patients And Methods:
We report an unusual case of recall dermatitis induced 3 months after initiation of vemurafenib and cobimetinib therapy.
Discussion:
Radiation recall dermatitis is a cutaneous reaction that must be known and which in rare cases such as ours may occur a long time after the end of radiotherapy.
Insights
Radiation recall dermatitis, an inflammatory skin reaction, can occur years after radiotherapy. This case highlights BRAF and MEK inhibitors as rare triggers for this delayed reaction.
Area of Science:
- Dermatology
- Oncology
- Pharmacology
Background:
- Radiation recall dermatitis (RRD) is an uncommon inflammatory skin reaction occurring at prior radiation sites.
- It typically presents days to years after radiotherapy and is often triggered by systemic medications.
- While certain drugs are known triggers, BRAF and MEK inhibitors are rarely implicated.
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