Related Experiment Video
Updated: Jan 26, 2026
09:41
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
12.0K
Multiple Deeply Divergent Denisovan Ancestries in Papuans
Guy S Jacobs1, Georgi Hudjashov2, Lauri Saag3
1Complexity Institute, Nanyang Technological University, Singapore 637723, Singapore.
Cell
|April 15, 2019
Summary
Modern humans interbred with multiple Denisovan groups, not just one. Ancient DNA analysis reveals distinct Denisovan lineages in Papuans and East Asians, indicating complex archaic hominin interactions.
Area of Science:
- Human Evolution
- Paleogenetics
- Population Genetics
Background:
- Genome sequences of Neanderthals and Denisovans are known.
- Archaic hominins interbred with modern humans dispersing from Africa.
Purpose of the Study:
- To investigate archaic DNA in modern populations of Island Southeast Asia and New Guinea.
- To determine the origin and complexity of archaic hominin introgression.
Main Methods:
- Analysis of 161 new genomes from Island Southeast Asia and New Guinea.
- Identification of high-confidence archaic haplotypes.
- Comparison with known archaic hominin genomes.
Main Results:
- High-confidence archaic haplotypes were identified in 161 new genomes.
- Modern Papuans carry gene variants from two deeply divergent Denisovan lineages.
- A third Denisovan lineage was found in modern East Asians.
Conclusions:
- Introgression involved multiple, geographically isolated Denisovan groups.
- Denisovan lineages separated over 350,000 years ago.
- Archaic hominin contact was complex, with regional variations.
Related Concept Videos
01:15Divergence and Curl
3.1K
The divergence of a vector field at a point is the net outward flow of the flux out of a small volume through a closed surface enclosing the volume, as the volume tends to zero. More practically, divergence measures how much a vector field spreads out or diverges from a given point. For an outgoing flux, conventionally, the divergence is positive. The diverging point is often called the "source" of the field. Meanwhile, the negative divergence of a vector field at a point means that the vector...
3.1K
01:06Divergence and Stokes' Theorems
3.6K
The divergence and Stokes' theorems are a variation of Green's theorem in a higher dimension. They are also a generalization of the fundamental theorem of calculus. The divergence theorem and Stokes' theorem are in a way similar to each other; The divergence theorem relates to the dot product of a vector, while Stokes' theorem relates to the curl of a vector. Many applications in physics and engineering make use of the divergence and Stokes' theorems, enabling us to write...
3.6K
02:37Gene Duplication and Divergence
7.9K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
7.9K
01:25Divergence and Curl of Electric Field
7.2K
The divergence of a vector is a measure of how much the vector spreads out (diverges) from a point. For example, an electric field vector diverges from the positive charge and converges at the negative charge. The divergence of an electric field is derived using Gauss's law and is equal to the charge density divided by the permittivity of space. Mathematically, it is expressed as
7.2K
01:26Divergence and Curl of Magnetic Field
4.0K
The magnetic field due to a volume current distribution given by the Biot–Savart Law can be expressed as follows:
4.0K
01:49Multiple Allele Traits
38.0K
The Concept of Multiple Allelism
38.0K