[Screening of human and animal tissue cell cultures as potential producers of plasminogen activator]

Twenty six normal cell cultures and 19 tumor cell cultures were subjected to screening for plasminogen activator (PA), a fibrinolytic enzyme. It was shown that the enzyme production depended on the nature, origin, type and species of the tissue culture. The primary cultures of the human and calf embryonic kidney cells, permanent cell lines and tumor cells possessed high PA activity. The suspension cell lines did not produce the PA.