Related Experiment Video

Updated: Jan 26, 2026

Study of Experimental Organ Donation Models for Lung Transplantation
08:56

Study of Experimental Organ Donation Models for Lung Transplantation

Published on: March 15, 2024

2.1K

Long-term risk for kidney donors with hypertension at donation - a retrospective cohort study

Anders J Haugen1,2, Nina E Langberg1, Dag Olav Dahle1

  • 1Department of Transplant Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Transplant International : Official Journal of the European Society for Organ Transplantation
|April 16, 2019
PubMed

Insights

Hypertension in kidney donors does not appear to increase long-term mortality risk. This study suggests older kidney donors with high blood pressure may still be suitable candidates for donation.

Area of Science:

  • Nephrology
  • Cardiology
  • Transplantation

Background:

  • Elevated blood pressure (hypertension) is linked to increased mortality in the general population.
  • The long-term impact of hypertension on kidney donor mortality is less understood.
  • Kidney donation involves careful donor selection to ensure long-term health outcomes.

Purpose of the Study:

  • To evaluate the association between hypertension at the time of kidney donation and long-term overall and cardiovascular mortality.
  • To compare mortality rates in hypertensive kidney donors versus normotensive kidney donors.
  • To inform donor selection criteria regarding pre-existing hypertension.

Main Methods:

  • Retrospective analysis of 2131 kidney donors with available records.
  • Hypertension defined as blood pressure >140/90 mmHg or antihypertensive medication use.
  • Multivariable regression analyses to assess overall and cardiovascular mortality after a median follow-up of 20.8 years.

Main Results:

  • Hypertensive donors were older, more likely male, had higher BMI, and lower estimated glomerular filtration rate (eGFR).
  • Multivariable analysis showed no significant association between hypertension at donation and increased long-term overall mortality (HR 1.1, 95% CI 0.9-1.5).
  • No significant association was found between hypertension at donation and increased long-term cardiovascular mortality (HR 1.1, 95% CI 0.7-1.8).

Conclusions:

  • Hypertension at the time of kidney donation does not appear to be a contraindication for donation.
  • These findings may support the inclusion of older, otherwise healthy kidney donors with hypertension.
  • Further research could explore the impact of controlled hypertension on donor outcomes.

Keywords:
cardiovascular eventshypertensionkidney donationkidney transplantationmortality risk

More Related Videos

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death09:54

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

Published on: August 15, 2022

2.3K
Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study03:05

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

563

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
491
Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
317
Kidney Structure01:45

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
75.1K
Relative Risk01:12

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.0K
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.2K
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
803