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Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases
Published on: November 22, 2024
[Current situation of malaria in the world]
Bruno Pradines1, Marie-Gladys Robert2
1Unité de parasitologie et entomologie, département de microbiologie et de maladies infectieuses, Institut de recherche biomédicale des armées, Marseille, France. Centre national de référence du paludisme, Institut de recherche biomédicale des armées, IHU Méditerranée Infection, Marseille, France.
Malaria remains a global threat, with millions of cases and hundreds of thousands of deaths annually, particularly affecting children under five. Drug resistance and stagnant progress highlight the need for sustained malaria control efforts.
Area of Science:
- Global Health
- Infectious Diseases
- Epidemiology
Background:
- Malaria poses a significant global health risk, with nearly half the world's population at risk in 2016.
- The disease disproportionately affects specific regions, with Africa bearing the largest burden of cases and deaths.
Purpose of the Study:
- To outline the current global malaria situation, including case numbers, mortality rates, and at-risk populations.
- To identify trends in malaria incidence and mortality, and highlight challenges in control and elimination efforts.
Main Methods:
- Analysis of global malaria data from 2016, focusing on case distribution, mortality, and population risk.
- Review of trends in malaria cases and deaths since 2000, considering factors like funding and drug resistance.
Main Results:
- In 2016, an estimated 216 million malaria cases and 445,000 deaths occurred globally, with 90% of cases and 91% of deaths in Africa.
- Children under five accounted for 66% of malaria-related deaths, underscoring their vulnerability.
- Despite control funding, malaria cases increased since 2013, and deaths have stagnated since 2015, with emerging drug resistance noted.
Conclusions:
- Malaria control and elimination demand sustained, long-term, and intensified efforts.
- Addressing drug resistance and protecting vulnerable populations, especially young children, are critical for future progress.
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