Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

721
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
721
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

630
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
630
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

839
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
839
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

611
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
611
Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

2.9K
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
2.9K
Induced-fit Model01:13

Induced-fit Model

89.0K
Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
89.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chemotherapy-induced nausea and vomiting in the literature: a cross-sectional analysis by time and emetogenicity.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026
Same author

<i>Supportive Care in What</i>? Myths and Misconceptions That Prevent the Provision of Excellent Cancer Care.

JCO global oncology·2026
Same author

Editorial.

Current opinion in oncology·2026
Same author

Comparing clinical practice guidelines on the prevention and management of chemotherapy-induced hand-foot syndrome.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026
Same author

Multi-disciplinarity in cancer care: a call for a global framework to deliver equitable and effective supportive care.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026
Same author

Prevalence of antibody drug conjugated-induced nausea and vomiting (ADCINV) in patients with cancer.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026

Related Experiment Video

Updated: Jan 26, 2026

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
05:56

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting

Published on: June 21, 2024

2.0K

[Nausea and vomiting induced by chemotherapy].

Florian Scotté1, Mathilde Chastenet1, Pauline Leroy1

  • 1Département d'oncologie médicale et soins de support, hôpital Foch, Suresnes, France.

La Revue Du Praticien
|April 16, 2019
PubMed
Summary

Chemotherapy-induced nausea and vomiting (CINV) significantly affects cancer treatment safety. Effective management requires accurate assessment, adherence to guidelines, and involvement of healthcare professionals for optimal emesis protection.

Keywords:
cancernauseasupportive carevomiting

More Related Videos

Author Spotlight: Alleviating Nausea and Vomiting in Pregnancy with Safe and Effective Auricular Acupuncture
05:33

Author Spotlight: Alleviating Nausea and Vomiting in Pregnancy with Safe and Effective Auricular Acupuncture

Published on: August 4, 2023

2.3K
Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
07:05

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Published on: May 12, 2019

6.5K

Related Experiment Videos

Last Updated: Jan 26, 2026

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
05:56

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting

Published on: June 21, 2024

2.0K
Author Spotlight: Alleviating Nausea and Vomiting in Pregnancy with Safe and Effective Auricular Acupuncture
05:33

Author Spotlight: Alleviating Nausea and Vomiting in Pregnancy with Safe and Effective Auricular Acupuncture

Published on: August 4, 2023

2.3K
Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
07:05

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Published on: May 12, 2019

6.5K

Area of Science:

  • Oncology
  • Clinical Pharmacy

Background:

  • Chemotherapy-induced nausea and vomiting (CINV) is a significant adverse effect of anticancer treatments.
  • CINV impacts patient quality of life and treatment adherence.
  • Effective management of CINV is crucial for maintaining the safety and efficacy of chemotherapy.

Purpose of the Study:

  • To highlight the importance of accurate definition, frequent assessment, and perfect treatment of chemotherapy-induced nausea and vomiting.
  • To discuss the role of new treatments and existing medications in emesis protection.
  • To emphasize the necessity of multidisciplinary team involvement in managing CINV.

Main Methods:

  • Review of current guidelines and literature on chemotherapy-induced nausea and vomiting management.
  • Discussion of established and emerging therapeutic strategies for emesis control.
  • Emphasis on the collaborative role of physicians, nurses, and caregivers.

Main Results:

  • Accurate assessment and guideline-adherent treatment are essential for managing CINV.
  • New therapeutic agents are under development for improved emesis protection.
  • The involvement of all healthcare professionals is critical for successful CINV management.

Conclusions:

  • Chemotherapy-induced nausea and vomiting is a key topic in cancer care.
  • Optimal management involves a comprehensive approach including patient assessment, guideline adherence, and professional collaboration.
  • Continued research and development in emesis protection are vital for improving patient outcomes.