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Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System
Published on: October 29, 2019
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Antisense Oligonucleotide: Basic Concepts and Therapeutic Application in Inflammatory Bowel Disease.
Davide Di Fusco1, Vincenzo Dinallo1, Irene Marafini1
1Department of Systems Medicine, Gastroenterology, University of Tor Vergata, Rome, Italy.
Frontiers in Pharmacology
|April 16, 2019
Summary
Antisense technology offers a precise method to regulate gene expression for treating inflammatory diseases. This review explores oligonucleotide therapeutics for inflammatory bowel diseases (IBD), including Crohn
Area of Science:
- Molecular biology
- Genetics
- Immunology
Background:
- Inflammatory and neoplastic diseases are targeted by novel gene expression regulation technologies.
- Antisense technology inhibits gene expression by targeting cellular RNAs.
- Understanding molecular mechanisms in inflammatory bowel diseases (IBD) like Crohn's disease (CD) and ulcerative colitis (UC) reveals new therapeutic targets.
Purpose of the Study:
- To provide a comprehensive understanding of oligonucleotide therapeutics.
- To review pre-clinical and clinical data on oligonucleotide-based therapy for IBD.
Main Methods:
- Review of scientific literature on antisense technology and oligonucleotide therapeutics.
- Analysis of pre-clinical and clinical data for IBD treatment.
Main Results:
- Antisense technology is a specific and rapid method for gene expression inhibition.
- Advances in IBD molecular mechanisms have identified new therapeutic targets.
- Oligonucleotide therapeutics show promise for IBD treatment.
Conclusions:
- Oligonucleotide therapeutics represent a promising strategy for managing inflammatory bowel diseases.
- Further research and clinical application of these therapies are warranted.
Keywords:
Crohn’s diseaseRNA interferenceantisense oligonucleotideinflammatory bowel diseaseulcerative colitisMore Related Videos
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