Related Experiment Video
Updated: Jan 26, 2026
11:02
Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
Published on: April 13, 2022
4.1K
Stem cells and tooth regeneration: prospects for personalized dentistry
Mahmood S Mozaffari1, Golnaz Emami1, Hesam Khodadadi1
1Department of Oral Biology and Diagnostic Sciences; CL-2134, Dental College of Georgia, Augusta University, Augusta, GA 30912-1128 USA.
The EPMA Journal
|April 16, 2019
Summary
Regenerative dentistry utilizes stem cells from various sources, including teeth, to repair oral diseases. Advances in personalized dentistry aim to create custom teeth and structures for tailored treatments.
Area of Science:
- Biomedical Engineering
- Dental Science
- Regenerative Medicine
Background:
- Extensive research exists on stem cells for regenerative purposes.
- Adult stem cells are a focus for regenerative engineering, growth factors, and scaffolding.
- Tooth-derived stem cells and induced pluripotent stem cells offer new avenues for regenerative dentistry.
Purpose of the Study:
- To review advancements in regenerative dentistry.
- To explore the application of stem cells in treating oral diseases like dental caries and periodontal diseases.
- To discuss the potential of personalized dentistry through custom-made tooth regeneration.
Main Methods:
- Review of current literature on stem cell sources and applications in dentistry.
- Analysis of induced pluripotent stem cells for dental complex generation.
- Exploration of small molecules for augmenting endogenous regenerative capacity.
Main Results:
- Tooth-derived stem cells show promise for treating prevalent oral diseases.
- Induced pluripotent stem cells enable patient-specific regenerative therapies.
- Small molecules can regulate molecular signaling for tooth structure regeneration.
Conclusions:
- Regenerative dentistry is advancing towards "personalized dentistry" with custom-made tooth and tissue regeneration.
- Stem cell therapies, including those from teeth and induced pluripotent stem cells, are key to future dental treatments.
- Targeted molecular signaling offers a complementary approach to enhance natural tooth repair mechanisms.
Related Concept Videos
01:21Stem Cell Therapy for Tissue Regeneration
4.6K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.6K
01:21Tooth Anatomy
2.1K
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
2.1K
01:33Adult Stem Cells
33.4K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.4K
00:58Embryonic Stem Cells
32.1K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.1K
01:13Induced Pluripotent Stem Cells
27.3K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
27.3K
01:25Personal Identity
342
Personal identity is the deeply felt sense of self that individuals cultivate over time, intricately woven from intrinsic qualities they consider essential to their existence—qualities such as morality, intelligence, and friendliness. These attributes serve as vital internal benchmarks, guiding individuals in evaluating whether their actions resonate with their true selves.When personal identity takes center stage in one's life, individuals often emphasize their distinctiveness,...
342