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Does testosterone affect the normal menstrual cycle?

P Dewis, M Newman, W A Ratcliffe

    Clinical Endocrinology
    |May 1, 1986
    PubMed
    Summary
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    Elevated testosterone levels did not disrupt menstrual cycles or hormone fluctuations in ovulating women. This suggests that excessive testosterone is not the primary cause of menstrual issues in polycystic ovary syndrome (PCOS).

    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Gynecology

    Background:

    • Polycystic ovary syndrome (PCOS) is associated with androgen excess.
    • The precise role of androgens in PCOS-related menstrual dysfunction requires further elucidation.

    Purpose of the Study:

    • To investigate the impact of artificially elevated serum testosterone on menstrual function and hormonal profiles in ovulating women.
    • To gather indirect evidence regarding the aetiology of menstrual disturbances in PCOS.

    Main Methods:

    • Six ovulating women with severe premenstrual syndrome or loss of libido received testosterone implants (100 mg).
    • Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), progesterone, and testosterone were measured pre-implantation and during the first and third cycles post-implantation.

    Related Experiment Videos

  • Sex hormone-binding globulin (SHBG) levels were also monitored.

    • Main Results:

    • Markedly elevated serum testosterone levels (mean increase from 1.3 to 7.1 nmol/l) did not alter menstrual cycle patterns.
    • Cyclical variations in LH, FSH, E2, and progesterone remained normal throughout the study.
    • A non-significant decrease in luteal phase E2 and progesterone was observed.
    • SHBG levels decreased by 18.5% during the first cycle post-implantation.

    Conclusions:

    • Significant elevation of serum testosterone does not appear to disrupt normal ovulatory menstrual cycles in women.
    • These findings suggest that excessive ovarian or adrenal testosterone production may not be the primary driver of menstrual disturbances in PCOS.