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Tissue Engineering in Pediatric Bladder Reconstruction-The Road to Success
Maya Horst1,2, Daniel Eberli2, Rita Gobet1
1Laboratory for Urologic Tissue Engineering and Stem Cell Therapy, Department of Urology, University Hospital, Zurich, Switzerland.
Frontiers in Pediatrics
|April 16, 2019
Summary
Tissue engineering offers a promising alternative to traditional bladder augmentation for children, aiming to avoid complications associated with intestinal tissue use. This review explores advancements and hurdles in creating functional, engineered bladder tissue for pediatric patients.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Pediatric Urology
Background:
- Congenital disorders can lead to end-stage bladder disease in children, often requiring bladder augmentation.
- Enterocystoplasty, using intestinal segments, is the current standard but carries significant risks like metabolic issues, stones, infections, and malignancy.
- Engineered bladder tissue presents an alternative to reduce complications associated with bowel use in reconstruction.
Purpose of the Study:
- To review the progress in bladder tissue engineering for pediatric applications.
- To identify key challenges hindering clinical translation of engineered bladder substitutes.
- To discuss strategies for developing functional, long-lasting engineered bladder replacements.
Main Methods:
- Review of current literature on bladder tissue engineering strategies.
- Analysis of achievements in regenerative approaches for bladder reconstruction.
- Discussion of obstacles in clinical implementation and potential solutions.
Main Results:
- Significant advancements have been made in bladder tissue regeneration techniques.
- Challenges remain in achieving seamless clinical translation and long-term functionality.
- Various strategies are being explored to overcome these obstacles for pediatric use.
Conclusions:
- Bladder tissue engineering holds potential to revolutionize pediatric urology by providing safer alternatives to enterocystoplasty.
- Overcoming challenges in growth potential and long-term viability is crucial for clinical success.
- Further research and development are needed to meet the demand for functional, living bladder replacements in children.
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