Related Experiment Video
Updated: Jan 26, 2026

Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome ARDS
Published on: September 7, 2016
Improvement in Oxygenation Utilizing Transpulmonary Pressure Monitoring for Optimal Positive End-Expiratory Pressure
Stephen J Gleich1, Brenda M Schiltz2, Yves Ouellette2
1From the Departments of Anesthesiology and Perioperative Medicine.
Insights
Measuring transpulmonary pressure using esophageal manometry helped optimize positive end-expiratory pressure in a child with severe pediatric acute respiratory distress syndrome. This approach rapidly improved oxygenation and led to survival without complications.
Area of Science:
- Pediatric Critical Care Medicine
- Respiratory Physiology
- Neonatology
Background:
- Severe pediatric acute respiratory distress syndrome (PARDS) lacks established methods for optimal positive end-expiratory pressure (PEEP) titration.
- Refractory hypoxemia is a significant challenge in managing severe PARDS.
Abstract:
In severe pediatric acute respiratory distress syndrome, data are lacking on methods to measure and set optimal positive end-expiratory pressure. We present a 2-year-old girl with Trisomy 21 who developed severe pediatric acute respiratory distress syndrome and refractory hypoxemia from human metapneumovirus pneumonia. Esophageal manometry was utilized to measure transpulmonary pressure, and positive end-expiratory pressure was increased to 19 cm H2O, resulting in rapid improvement in oxygenation. Hemodynamics remained adequate without intervention. The patient improved and survived without sequelae. Our case suggests that transpulmonary pressure monitoring should be studied as an adjunct to improve outcomes in pediatric acute respiratory distress syndrome.
More Related Videos
Related Concept Videos
Vapor Pressure
Definition and Measurement of Pressure: Atmospheric Pressure, Barometer, and Manometer
Errors occurring during blood pressure monitoring
Several factors...
Constant Pressure Calorimetry
Vapor Pressure Lowering
Osmosis and Osmotic Pressure of Solutions

