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Updated: Jan 26, 2026

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo
Published on: November 8, 2018
Comparative Analysis of the Transcriptome and Proteome during Mouse Placental Development
Majd Abdulghani1,2, Gaoyuan Song3, Haninder Kaur2
1Interdepartmental Genetics and Genomics , Iowa State University , Ames , Iowa 50011-1079 , United States.
This study reveals key genes regulating early placental development by combining multiple data types. The findings offer new insights into placental gene regulation for improved maternal and fetal health.
Area of Science:
- Reproductive Biology
- Developmental Biology
- Genomics
Background:
- Placental health is crucial for maternal and fetal outcomes.
- Early placental development, including trophoblast invasion and metabolism, is not fully understood.
Purpose of the Study:
- To identify genes regulating early placental development.
- To understand trophoblast migration and placental metabolism.
Main Methods:
- Multiomics approach using mouse placental tissue.
- Integrated analysis of transcriptome, proteome, and phosphoproteome data.
- Examined two critical developmental time points.
Main Results:
- Combining transcriptome and proteome data identified time-specific biological processes.
- Identified 27 predicted genes involved in trophoblast migration or placental metabolism.
- Discovered novel phosphosites regulating placental transcription factors.
Conclusions:
- Multiomics integration provides deeper insights into placental gene regulation.
- This study advances understanding of early placental development.
- Findings contribute to improving maternal and fetal health outcomes.
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