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Updated: Jan 26, 2026
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Adult Zebrafish Injury Models to Study the Effects of Prednisolone in Regenerating Bone Tissue
Published on: October 18, 2018
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Vitamin E and Selenium Reduce Prednisolone Side Effects in Rat Hearts
Ebru Bardas1, Yusuf Kemal Arslan2, Seher Polat3
1Department of Medical Physiology, Faculty of Medicine, University of Erzincan, Erzincan, Turkey.
Summary
Dietary vitamin E and selenium supplementation may protect heart tissue from prednisolone-induced oxidative stress. These antioxidants helped reduce lipid peroxidation and maintain antioxidant enzyme activity in rats.
Area of Science:
- Biochemistry
- Pharmacology
- Nutritional Science
Background:
- High-dose prednisolone treatment can induce oxidative stress in heart tissues.
- Oxidative stress is characterized by increased lipid peroxidation and decreased antioxidant enzyme activity.
- Vitamin E and selenium are known antioxidants with potential protective effects.
Purpose of the Study:
- To investigate the effects of dietary vitamin E and selenium on lipid peroxidation (LPO) and antioxidant defense mechanisms in rat heart tissue.
- To evaluate the protective role of vitamin E and selenium against prednisolone-induced oxidative damage.
Main Methods:
- Adult male Wistar rats were divided into five groups.
- Groups received either a normal diet or supplemented diets with vitamin E, selenium, or a combination.
- Prednisolone was administered intramuscularly to four groups, while one control group received a placebo.
- Heart tissues were analyzed for Thiobarbituric acid reactive substances (TBARS), glutathione (GSH) levels, and antioxidant enzyme activities (GSH-Px, CAT).
Main Results:
- Prednisolone administration significantly decreased antioxidant enzyme activities and GSH levels, while increasing TBARS levels in heart tissue.
- Vitamin E and selenium supplementation inhibited the increase in TBARS and attenuated the decrease in antioxidant enzyme activities.
- The protective effects were observed in rats supplemented with vitamin E, selenium, or their combination.
Conclusions:
- Dietary vitamin E and selenium demonstrate a preventive role against prednisolone-induced lipid peroxidation in rat heart tissue.
- These antioxidants may help mitigate oxidative stress by maintaining the balance of antioxidant defense mechanisms.
- Further research is warranted to explore the clinical implications of vitamin E and selenium in patients receiving corticosteroid therapy.
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