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Precision medicine offers tailored treatments for obstructive sleep apnoea (OSA). New tools describe OSA complexity and guide personalized management based on individual patient traits.

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Area of Science:

  • Sleep Medicine
  • Respiratory Medicine
  • Precision Medicine

Background:

  • Obstructive sleep apnoea (OSA) is a complex and heterogeneous condition.
  • Current diagnostic and management strategies for OSA are limited.
  • Precision medicine aims to provide individually tailored treatments.

Purpose of the Study:

  • To propose novel tools for describing and managing obstructive sleep apnoea (OSA).
  • To facilitate the implementation of precision medicine in clinical practice for OSA.
  • To address the complexity of OSA through a trait-based approach.

Main Methods:

  • Development of a control panel tool to characterize OSA across four domains: severity, biological activity, patient impact, and pathophysiological traits.
  • Introduction of a graphical clinical fingerprint tool for longitudinal patient tracking.
  • Focus on identifying and utilizing treatable traits for personalized management.

Main Results:

  • The proposed tools offer a comprehensive description of OSA.
  • These instruments facilitate the tracking of patient progress over time.
  • The approach enables physicians to tailor treatment based on individual patient characteristics.

Conclusions:

  • The developed tools can effectively manage the complexity of OSA.
  • Physician decision-making can be guided by patient-specific, treatable traits.
  • This facilitates the clinical application of precision medicine for obstructive sleep apnoea.