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The association between CD69 and EGR1 levels, and CHD patients without reflow after PCI

Yi Xiang1, Jianqiao Peng2, Qiong Liu2

  • 1Department of Geriatrics, People's Hospital of Hunan Province, Changsha, Hunan 410006, P.R. China.

Experimental and Therapeutic Medicine
|April 17, 2019
PubMed

Insights

Investigating CD69 and EGR1 levels in coronary heart disease (CHD) patients undergoing percutaneous coronary intervention (PCI) revealed their association with no-reflow events. Elevated CD69 and decreased EGR1 indicate potential no-reflow, aiding timely intervention.

Area of Science:

  • Cardiology
  • Biomarkers
  • Interventional Cardiology

Background:

  • Percutaneous coronary intervention (PCI) is a common procedure for coronary heart disease (CHD).
  • No-reflow phenomenon after PCI can lead to adverse cardiac events and poorer prognosis.
  • Identifying reliable biomarkers for predicting no-reflow is crucial for patient management.

Purpose of the Study:

  • To investigate the association between CD69 and EGR1 levels and the occurrence of no-reflow in CHD patients post-PCI.
  • To determine if CD69 and EGR1 can serve as predictive markers for no-reflow after PCI.

Main Methods:

  • A cohort of 156 CHD patients undergoing PCI were divided into reflow (n=72) and no-reflow (n=84) groups.
  • A control group (n=70) of healthy volunteers was included for comparison.
  • Serum CD69 and EGR1 levels were measured using flow cytometry and RT-qPCR at various time points before and after PCI.

Main Results:

  • CD69 expression was significantly altered in the reflow group compared to baseline and controls.
  • CD69 levels were significantly lower in the reflow group than the no-reflow group, and higher in the no-reflow group than controls.
  • EGR1 levels were significantly higher in the reflow group than the no-reflow group, and lower in the no-reflow group than controls.
  • Multivariate analysis identified CD69 and EGR1 as independent risk factors for no-reflow post-PCI.

Conclusions:

  • CD69 and EGR1 levels are significantly associated with no-reflow phenomenon in CHD patients after PCI.
  • Increased CD69 and decreased EGR1 in the early postoperative period may predict no-reflow, enabling timely intervention.
  • These biomarkers could potentially improve therapeutic outcomes for CHD patients undergoing PCI.

Keywords:
CD69EGR1coronary heart diseaseno-reflowpercutaneous coronary intervention

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