Development of multiple organ dysfunction syndrome in older and young adult trauma patients

We sought out to determine the correlation between the injury severity score (ISS) and multiple organ dysfunction syndrome (MODS) between severely injured young adults (18-54 years) and elderly (>55 years) patients.

This was a cross-sectional observational study. We included all adult cases (>18 years) diagnosed with trauma defined by the International Classification of Diseases, Ninth Revision. For significance testing, Chi-square test and odds ratio were used. Severe injuries were defined by an ISS >15. The presence of MODS was based on the definitions proposed by society for critical care medicine.

A total of 469 young and 173 elderly patients were included in the study. Among the 469 young adults, 193 had ISS >15, whereas out of the 173 elderly patients, 88 had an ISS >15. Severely injured young and elderly groups were more likely to develop MODS compared with those with an ISS <15 (P < 0.001 and P < 0.001, respectively). The elderly had a higher likelihood of developing MODS (P < 0.001; odds ratio: 5.17; 95% confidence interval: 2.74-9.80).

This study demonstrated a direct relationship between an ISS >15 and the development of MODS. We also observed a five-fold increase in the development of MODS among severely injured elderly patients.