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Updated: Jan 26, 2026

Assembly, Loading, and Alignment of an Analytical Ultracentrifuge Sample Cell
Published on: November 5, 2009
EDC-Induced Self-Assembly of BSA-Au NCs
Wenli Zhu1, Huili Li2, Ajun Wan3
1Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, and School of Pharmacy, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai, 200240, China.
Abstract:
In this paper, the Au nanoplate with bright red fluorescence was synthesized on the basis of bovine serum albumin stabilized Au nanoclusters (BSA-Au NCs). The small molecule N-ethyl-N'-(dimethylaminopropyl) carbodiimide (EDC) was used as the cross-linking agent to activate the carboxyl group on the surface of BSA, and then the condensation with amino acid in BSA induced the self-assembly of BSA-Au NCs. The particle size of Au nanoplate increased with EDC concentration. In addition, when EDC concentration was 0.0050 M, the Au nanoplate changed from smooth to grainy structure. The Au nanoplate remained the unique fluorescence characteristics of BSA-Au NCs. As EDC concentration reached 0.0025 M, the Au nanoplate even exhibited brighter red emission than that of BSA-Au NCs.
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