Editors' Favorites: Best of 2018

Discovery of VU6052959/BI'7927: A Selective mGlu3 Positive Allosteric Modulator (PAM) from an Orthogonal Benzoxazine Chemotype.

ACS medicinal chemistry letters·2026

Discovery of VU6081679, a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 8 with Efficacy in a Preclinical Model of Parkinson's Disease.

ACS chemical neuroscience·2026

Optimization of Pyrazole-Based Activators of Kv3.1.

ACS medicinal chemistry letters·2026

Discovery of VU6077564: A Selective M1 Antagonist That Promotes Neurite Outgrowth in Adult Sensory Neurons.

ACS chemical neuroscience·2026

Discovery of VU6066098: A Selective and CNS-Penetrant mGlu2 NAM with Robust Antidepressant-, Antipsychotic-, and Procognitive-like Activity in Rodents.

ACS chemical neuroscience·2026

Discovery of VU6053371/BI03738809: A First-in-Class Selective and CNS-Penetrant mGlu3 Positive Allosteric Modulator (PAM) with Efficacy in a Preclinical Cognition Model.

ACS chemical neuroscience·2026

Body Temperature and Discriminative Stimulus Effects of Nicotine and Menthol Aerosols in Male Rats: Role of α4β2 Nicotinic Acetylcholine Receptors.

ACS chemical neuroscience·2026

Protein Aggregates as Drivers of Receptor Clustering and Pathological Signaling: A Framework Linking Extracellular Amyloid-β to Tau Dysregulation.

ACS chemical neuroscience·2026

Mechanistic Characterization of NABi as a Selective Inhibitor of SOD1G93A Aggregation: Structural Basis and Therapeutic Implications for ALS.

ACS chemical neuroscience·2026

Development and Preclinical Evaluation of a Novel PET Probe for Phosphodiesterase 7B Imaging in Brain.

ACS chemical neuroscience·2026

Nitrogen Doping Reduces the Neurotoxic Effects of Graphene Quantum Dots by Suppressing Proinflammatory and Oxidative Stress Pathways.

ACS chemical neuroscience·2026

Development of Novel Pegylated Imidazobenzodiazepines Targeting α5 GABAA Receptors for Anxiety: A Comparative Prodrug and Metabolite Study.

ACS chemical neuroscience·2026

Editorial: How to get published - nine golden rules of writing.

Child and adolescent mental health·2026

Building better citation practices in public health research: Practical considerations for student researchers, from source discovery to crafting and positioning claims.

PLOS global public health·2026

Predoctoral grant writing among physician-scientist trainees: A national survey of barriers and facilitators of success.

JCI insight·2026

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Editors' Favorites: Best of 2018

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Discovery of VU6052959/BI'7927: A Selective mGlu3 Positive Allosteric Modulator (PAM) from an Orthogonal Benzoxazine Chemotype.

Discovery of VU6081679, a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 8 with Efficacy in a Preclinical Model of Parkinson's Disease.

Optimization of Pyrazole-Based Activators of Kv3.1.

Discovery of VU6077564: A Selective M1 Antagonist That Promotes Neurite Outgrowth in Adult Sensory Neurons.

Discovery of VU6066098: A Selective and CNS-Penetrant mGlu2 NAM with Robust Antidepressant-, Antipsychotic-, and Procognitive-like Activity in Rodents.

Discovery of VU6053371/BI03738809: A First-in-Class Selective and CNS-Penetrant mGlu3 Positive Allosteric Modulator (PAM) with Efficacy in a Preclinical Cognition Model.

Body Temperature and Discriminative Stimulus Effects of Nicotine and Menthol Aerosols in Male Rats: Role of α4β2 Nicotinic Acetylcholine Receptors.

Protein Aggregates as Drivers of Receptor Clustering and Pathological Signaling: A Framework Linking Extracellular Amyloid-β to Tau Dysregulation.

Mechanistic Characterization of NABi as a Selective Inhibitor of SOD1G93A Aggregation: Structural Basis and Therapeutic Implications for ALS.

Development and Preclinical Evaluation of a Novel PET Probe for Phosphodiesterase 7B Imaging in Brain.

Nitrogen Doping Reduces the Neurotoxic Effects of Graphene Quantum Dots by Suppressing Proinflammatory and Oxidative Stress Pathways.

Development of Novel Pegylated Imidazobenzodiazepines Targeting α5 GABAA Receptors for Anxiety: A Comparative Prodrug and Metabolite Study.

Editorial: How to get published - nine golden rules of writing.

Building better citation practices in public health research: Practical considerations for student researchers, from source discovery to crafting and positioning claims.

Predoctoral grant writing among physician-scientist trainees: A national survey of barriers and facilitators of success.

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Editors' Favorites: Best of 2018

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