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Updated: Jan 26, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Published on: May 31, 2016

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Correlation between Aortic Calcification Score and Biochemical Parameters in Hemodialysis Patients

Noriaki Maruyama1, Terumi Higuchi2, Michiko Ono1

  • 1Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.

Contributions to Nephrology
|April 17, 2019
PubMed

Insights

Aortic calcification in hemodialysis patients correlates with age, dialysis duration, and biochemical markers. Key factors include age, dialysis time, pulse wave velocity, and mineral metabolism indicators.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Radiology

Background:

  • Aortic calcification is a common complication in patients undergoing hemodialysis.
  • Understanding factors associated with aortic calcification is crucial for risk stratification.

Purpose of the Study:

  • To investigate the correlation between aortic calcification and demographic/biochemical parameters in hemodialysis patients.

Main Methods:

  • Multi-slice computed tomography (CT) scans were used to assess aortic arch and abdominal aorta calcification using the Agatston score.
  • Demographic and biochemical parameters, including mineral metabolism and inflammation markers, were analyzed.
  • 190 hemodialysis patients were included in the study.

Main Results:

  • Significant positive correlations were observed between aortic calcification scores and age, hemodialysis duration, cardiothoracic ratio, normalized protein catabolic rate, brachial-ankle pulse wave velocity (baPWV), and markers of mineral metabolism and inflammation.
  • A negative correlation was found with platelet count.
  • Independent risk factors for aortic arch calcification included age, hemodialysis duration, baPWV, phosphate, calcium-phosphate product (Ca×P), parathyroid hormone, and C-reactive protein.
  • baPWV and Ca×P product were independent risk factors for abdominal aorta calcification.

Conclusions:

  • Aortic calcification in hemodialysis patients is associated with demographic factors like age and dialysis duration.
  • Biochemical parameters, particularly those related to mineral metabolism, inflammation, and vascular stiffness (baPWV), are significant contributors to aortic calcification.
Abstract

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