Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anatomy of the Ear01:16

Anatomy of the Ear

11.4K
Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
11.4K
Tumor Progression02:07

Tumor Progression

7.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.3K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.7K
Hearing01:31

Hearing

56.8K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
56.8K
What is the Skeletal System?01:02

What is the Skeletal System?

57.1K
Overview
57.1K
Characteristics of Life01:23

Characteristics of Life

257.7K
Biology is a natural science that studies life and living organisms, including their structure, function, development, interactions, evolution, distribution, and taxonomy. The field's scope is extensive and divided into several specialized disciplines, such as anatomy, physiology, ethology, genetics, and many more. All living things share a few key traits, including cellular organization, heritable genetic material and the ability to adapt/evolve, metabolism to regulate energy needs, the...
257.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Morphological appearance, content of extracellular matrix and vascular density of lung metastases predicts permissiveness to infiltration by adoptively transferred natural killer and T cells.

Cancer immunology, immunotherapy : CII·2005
Same author

Linear correlation between fractal dimension of EEG signal and handgrip force.

Biological cybernetics·2005
Same author

The -174 IL-6 GG genotype is associated with a reduced risk of type 2 diabetes mellitus in a family sample from the National Heart, Lung and Blood Institute's Framingham Heart Study.

Diabetologia·2005
Same author

Thymidylate synthase predicts for clinical outcome in invasive breast cancer.

Histology and histopathology·2005
Same author

The effect of transcranial magnetic stimulation on the latencies of vertical saccades.

Experimental brain research·2005
Same author

Intramembranous absorption rate is unaffected by changes in amniotic fluid composition.

American journal of physiology. Renal physiology·2005

Related Experiment Video

Updated: Jan 26, 2026

Discovering Middle Ear Anatomy by Transcanal Endoscopic Ear Surgery: A Dissection Manual
10:40

Discovering Middle Ear Anatomy by Transcanal Endoscopic Ear Surgery: A Dissection Manual

Published on: January 11, 2018

69.0K

[Progress in middle ear dysventilation research].

Q Yang1, Y Zhao2, Z Y Wang3

  • 1Department of Otorhinolaryngology Head and Neck Surgery, Shenzhen Sixth People's Hospital (Nanshan Hospital), Shenzhen 518052, China.

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Chinese Journal of Otorhinolaryngology Head and Neck Surgery
|April 18, 2019
PubMed
Summary
This summary is machine-generated.

Eustachian tube dysfunction can lead to middle ear negative pressure and tympanic membrane retraction pockets, potentially causing cholesteatoma. Selective epitympanic dysventilation syndrome explains attic cholesteatoma formation via tympanic isthmus blockage.

Keywords:
Endoscopic ear surgeryEustachian tubeMiddle ear ventilation

More Related Videos

High-Speed Human Temporal Bone Sectioning for the Assessment of COVID-19-Associated Middle Ear Pathology
03:42

High-Speed Human Temporal Bone Sectioning for the Assessment of COVID-19-Associated Middle Ear Pathology

Published on: May 18, 2022

2.6K
Dissection of the Auditory Bulla in Postnatal Mice: Isolation of the Middle Ear Bones and Histological Analysis
07:40

Dissection of the Auditory Bulla in Postnatal Mice: Isolation of the Middle Ear Bones and Histological Analysis

Published on: January 4, 2017

31.8K

Related Experiment Videos

Last Updated: Jan 26, 2026

Discovering Middle Ear Anatomy by Transcanal Endoscopic Ear Surgery: A Dissection Manual
10:40

Discovering Middle Ear Anatomy by Transcanal Endoscopic Ear Surgery: A Dissection Manual

Published on: January 11, 2018

69.0K
High-Speed Human Temporal Bone Sectioning for the Assessment of COVID-19-Associated Middle Ear Pathology
03:42

High-Speed Human Temporal Bone Sectioning for the Assessment of COVID-19-Associated Middle Ear Pathology

Published on: May 18, 2022

2.6K
Dissection of the Auditory Bulla in Postnatal Mice: Isolation of the Middle Ear Bones and Histological Analysis
07:40

Dissection of the Auditory Bulla in Postnatal Mice: Isolation of the Middle Ear Bones and Histological Analysis

Published on: January 4, 2017

31.8K

Area of Science:

  • Otolaryngology
  • Middle Ear Pathophysiology
  • Surgical Anatomy

Background:

  • Eustachian tube dysfunction is a common cause of middle ear pathologies.
  • Tympanic membrane retraction pockets, especially in the epitympanum, can progress to cholesteatoma.
  • Understanding selective ventilation pathways is crucial for diagnosing and treating attic cholesteatoma.

Purpose of the Study:

  • To review the theory of "selective epitympanic dysventilation syndrome" using endoscopic techniques.
  • To elucidate the mechanism by which isolated epitympanic dysfunction leads to cholesteatoma.
  • To highlight the role of the tympanic isthmus as the primary ventilation route to the epitympanum.

Main Methods:

  • Review of existing literature and clinical observations.
  • Endoscopic examination findings in patients with epitympanic cholesteatoma.
  • Theoretical analysis of middle ear ventilation pathways.

Main Results:

  • Selective epitympanic dysventilation syndrome is proposed as a mechanism for attic cholesteatoma.
  • The tympanic isthmus is identified as the critical ventilation pathway to the epitympanum.
  • Blockage of the tympanic isthmus can cause cholesteatoma even with recovered Eustachian tube function.

Conclusions:

  • Selective epitympanic dysventilation syndrome provides a framework for understanding isolated attic cholesteatoma.
  • Targeting the tympanic isthmus may be important in managing these specific cholesteatomas.
  • Endoscopic techniques aid in visualizing and understanding these ventilation dynamics.