Related Experiment Video

Updated: Jan 26, 2026

A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice
06:15

A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice

Published on: July 15, 2025

1.2K

Psychiatric Manifestations With Sacubitril/Valsartan: A Case Report

Jessica Wooster1, Elizabeth A Cook1, Denver Shipman1

  • 1University of Texas at Tyler, Ben and Maytee Fisch College of Pharmacy, Tyler, TX, USA.

Journal of Pharmacy Practice
|April 18, 2019
PubMed

Insights

Sacubitril/valsartan, a heart failure medication, may cause psychiatric side effects like paranoia and hallucinations. Discontinuation of the drug led to symptom resolution in a patient with heart failure with reduced ejection fraction.

Area of Science:

  • Cardiology
  • Neuroscience
  • Pharmacology

Background:

  • Sacubitril/valsartan is an established treatment for heart failure with reduced ejection fraction (HFrEF).
  • While valsartan is well-characterized, the neurocognitive effects of sacubitril, the neprilysin inhibitor component, require further investigation.
  • Understanding potential adverse effects is crucial for patient safety and optimizing therapy.

Observation:

  • A 31-year-old African American female with HFrEF experienced acute psychiatric symptoms including paranoia, delusions, and hallucinations after a sacubitril/valsartan dose increase.
  • The patient had no prior psychiatric history; symptoms emerged over 7 days.
  • Cranial CT revealed intracranial volume loss and mild ventricular enlargement, abnormal for age.

Findings:

  • Psychiatric symptoms resolved upon discontinuation of sacubitril/valsartan, indicating medication intolerance.
  • Laboratory tests and toxicology screens were negative, excluding infectious or substance-induced causes.
  • The observed neurological changes suggest a potential link between sacubitril/valsartan and central nervous system effects.

Implications:

  • This case highlights the potential for sacubitril/valsartan to induce psychiatric adverse effects, necessitating careful monitoring.
  • Further research into neprilysin inhibition's role in cognitive function is warranted.
  • Clinicians should consider psychiatric evaluation in HFrEF patients experiencing new-onset neurological or behavioral changes while on sacubitril/valsartan.

Keywords:
cognitiondementiaheart failureneprilysin inhibitorsacubitril/valsartan

More Related Videos

Developing a Behavioral Box for Assessing Prepulse Inhibition and Neural Activity in Psychiatric Animal Models06:55

Developing a Behavioral Box for Assessing Prepulse Inhibition and Neural Activity in Psychiatric Animal Models

Published on: July 22, 2025

705
Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats09:12

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

10.0K

Related Concept Videos

Data Reporting and Recording01:24

Data Reporting and Recording

Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
5.4K
Types of Reports I: Hands-off Report01:25

Types of Reports I: Hands-off Report

A hand-off report, also known as a change-of-shift report, is a crucial nursing process that ensures the smooth transition of patient care responsibilities between nursing staff.
Following are the key components and categories of hand-off reports:
Purpose and Process:
1.5K
Types of Reports II: Incident or Occurrence Report01:21

Types of Reports II: Incident or Occurrence Report

An Incident or Occurrence Report in a healthcare setting is a crucial document used to record any unexpected occurrence that may or may not have affected a patient, employee, or visitor. Such reports are critical to improving patient safety and include all details leading up to and including the event.
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
1.2K
Types of Reports III: Telephone and Verbal Reports01:26

Types of Reports III: Telephone and Verbal Reports

Telephone and Verbal Reports in healthcare settings are two communication methods for conveying therapeutic instructions from healthcare providers to nurses or other healthcare staff.
Here's an overview of each type:
Telephone Orders
1.0K
Reporter Genes02:11

Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
13.1K
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
817