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[Left ventricular function in hypertension treated with beta blockers].

R Gonzenbach, N Satz, W Vetter

    Schweizerische Medizinische Wochenschrift
    |November 4, 1978
    PubMed
    Summary
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    Atenolol, a beta-blocking agent, reduced blood pressure and heart rate in patients with essential hypertension. While initially decreasing left ventricular function, it showed improvement over 8 weeks, suggesting low risk for heart decompensation.

    Area of Science:

    • Cardiology
    • Pharmacology

    Context:

    • Essential hypertension poses risks to cardiovascular health, particularly left ventricular function.
    • Beta-blocking agents are commonly prescribed for hypertension management.

    Purpose:

    • To assess the effects of atenolol on left ventricular function in patients with essential hypertension.
    • To evaluate changes in cardiac parameters during 8 weeks of atenolol treatment.

    Summary:

    • 14 hypertensive patients received 100 mg/day oral atenolol.
    • Significant reductions in systolic and diastolic blood pressure and heart rate were observed after 4 weeks.
    • Left ventricular systolic shortening initially decreased but improved by week 8; end-diastolic diameter remained unchanged.

    Impact:

    Related Experiment Videos

    • Long-term atenolol therapy shows a transient reduction in left ventricular function, which recovers over time.
    • The observed functional changes are slight, indicating a low likelihood of inducing left heart decompensation.
    • Findings are particularly relevant for patients with initially normal left ventricular function.