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Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)
Hikaru Kato1, Momona Sebe1, Mika Nagaki1
1Graduate School of Pharmaceutical Sciences , Kumamoto University , 5-1 Oe-honmachi , Kumamoto 862-0973 , Japan.
Journal of Natural Products
|April 18, 2019
Abstract:
Four new norditerpenes, taichunins A-D (1-4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC50 value of 4.5 μM, whereas 2-4 were nontoxic at 50 μM.
