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Optimizing the Diagnosis of Parkinsonian Syndromes With 123I-Ioflupane Brain SPECT
Kevin P Banks1,2, Justin G Peacock1, Michael N Clemenshaw1,2
11 Department of Radiology, Brooke Army Medical Center, Fort Sam Houston, 3551 Roger Brooke Dr, San Antonio, TX 78234.
Abstract:
OBJECTIVE. The purpose of this article is to provide a review of 123I-ioflupane SPECT in the evaluation of suspected parkinsonian syndromes (PSs). This collection of diseases presents frequent diagnostic challenges, even by movement disorder and dementia specialists. CONCLUSION. The 123I-ioflupane scan serves as an imaging biomarker of the status of presynaptic dopamine transporters (DATs) in the striatum. As a result of neuronal death, DATs are greatly reduced in patients with PS neurodegenerative disorders, whereas clinical mimics generally do not show striatal DAT loss. This provides a tremendous opportunity for 123I-ioflupane to aid in the accurate and timely diagnosis of these patients and optimize their management.
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