Cognitive fatigue and cortical-striatal network in old age
Ping Ren1, Andrew J Anderson2,3, Kelsey McDermott1
1School of Nursing, University of Rochester Medical Center, Rochester, NY 14623, USA.
Aging
|April 18, 2019
Summary
Cognitive fatigue in older adults is linked to weaker connections in the brain's cortical-striatal network. This network
Area of Science:
- Neuroscience
- Aging Research
- Cognitive Psychology
Background:
- Cognitive fatigue (CF) is a common aging symptom impacting sustained mental effort.
- Understanding neural mechanisms underlying CF is crucial for healthy aging.
Purpose of the Study:
- To investigate the relationship between the cortical-striatal network and CF in healthy older adults.
- To explore if CF affects the Posterior-Anterior Shifting in Aging (PASA) phenomenon.
Main Methods:
- fMRI experiment with cognitively healthy older adults undergoing a 30-minute fatiguing task.
- Assessment of cognitive fatigue using the 18-item visual analogue scale.
- Analysis of cortical-striatal network connectivity and its correlation with CF and cognitive performance.
Main Results:
- Decreased cortical-striatal network connectivity correlated with higher cognitive fatigue.
- The relationship between CF and the cortical-striatal network was stronger in anterior than posterior regions.
- Enhanced reliance on the anterior cortical-striatal network benefited cognitive performance only in individuals with low CF.
Conclusions:
- The cortical-striatal network, particularly its anterior part, plays a key role in cognitive fatigue in aging.
- The Posterior-Anterior Shifting in Aging phenomenon may not apply to older adults susceptible to cognitive fatigue.
Keywords:
Posterior-Anterior Shifting in Agingcognitive fatiguefunctional MRIfunctional connectivitystriatumMore Related Videos
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