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IL17A Blockade Successfully Treated Psoriasiform Dermatologic Toxicity from Immunotherapy
Daniel Johnson1, Anisha B Patel2, Marc I Uemura1
1Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas.
Cancer Immunology Research
|April 19, 2019
Summary
Immune checkpoint inhibitors (ICIs) can cause skin toxicity. A patient
Area of Science:
- Oncology
- Immunology
- Dermatology
Background:
- Immune checkpoint inhibitors (ICIs) are crucial in cancer therapy.
- Dermatologic toxicities are common immune-related adverse events (irAEs) from ICIs.
- Current treatments for severe skin irAEs, like high-dose corticosteroids, have limitations and potential side effects.
Observation:
- A patient receiving PD-1 inhibitor pembrolizumab developed severe psoriasiform dermatologic toxicity.
- Standard treatments for high-grade skin irAEs were considered.
- The patient's condition presented a diagnostic and therapeutic challenge.
Findings:
- Systemic interleukin-17A (IL17A) blockade effectively resolved the psoriasiform skin toxicity.
- IL17A blockade did not compromise the patient's anti-melanoma response to pembrolizumab.
- This suggests a potential role for Th17 cells in mediating these skin irAEs.
Implications:
- Interleukin-17A (IL17A) blockade offers a potential alternative treatment for severe ICI-induced dermatologic toxicities.
- Targeting Th17 cells may be a viable strategy for managing skin irAEs without affecting antitumor efficacy.
- Further research is warranted to elucidate the role of Th17 cells in ICI-related adverse events.
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