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Dismantling the pathophysiology of asthma using imaging
Gregory G King1,2,3, Catherine E Farrow4,2,3, David G Chapman2,5
1Dept of Respiratory Medicine, Royal North Shore Hospital, St Leonards, Australia gregory.king@sydney.edu.au.
Summary
Advanced lung imaging can improve asthma management by revealing disease heterogeneity beyond current limited measures. This technology aids in better phenotyping, potentially leading to improved clinical trials and routine patient assessment.
Area of Science:
- Pulmonology
- Medical Imaging
- Respiratory Medicine
Background:
- Asthma is a significant global health burden with high patient and healthcare costs.
- Asthma is a heterogeneous disease, necessitating advanced phenotyping beyond spirometry and symptoms.
- Current asthma assessment methods are limited in capturing the full spectrum of pathophysiological processes.
Purpose of the Study:
- To highlight the need for advanced lung imaging in asthma research and clinical practice.
- To advocate for the integration of sophisticated imaging techniques for better asthma phenotyping.
- To emphasize the clinical relevance of imaging-derived structural and functional lung abnormalities.
Main Methods:
- Utilizing advanced three-dimensional lung imaging techniques, including computed tomography (CT) and ventilation imaging (SPECT, PET).
- Employing magnetic resonance imaging (MRI) and other lung imaging methods applicable to asthma research.
- Correlating imaging findings with clinical parameters such as disease severity and exacerbation risk.
Main Results:
- Sophisticated lung imaging methods are highly developed and applicable to asthma research.
- Abnormalities in structure and ventilatory function detected by imaging are clinically relevant.
- Imaging findings show associations with asthma severity, exacerbation risk, and airflow obstruction.
Conclusions:
- Advanced lung imaging provides crucial insights into asthma heterogeneity.
- Imaging techniques offer a more comprehensive assessment than traditional methods.
- Lung imaging is poised for broader adoption in clinical trials and routine asthma care.
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