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Invasive group A streptococcal disease: Management and chemoprophylaxis
Dorothy L Moore1, Upton D Allen1, Timothy Mailman1
1Canadian Paediatric Society, Infectious Diseases and Immunization Committee, Ottawa, Ontario.
Paediatrics & Child Health
|April 19, 2019
Summary
Invasive group A streptococcal disease (IGAS) is rising in Canada. This update focuses on IGAS chemoprophylaxis for contacts and clinical management, reaffirming penicillin
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Background:
- Invasive group A streptococcal disease (IGAS) reporting has increased in Canada.
- Variable adherence to existing Canadian IGAS guidelines necessitates an update.
- Optimal chemoprophylaxis and management are crucial for IGAS control.
Purpose of the Study:
- To update Canadian guidelines for IGAS chemoprophylaxis and clinical management.
- To provide clear recommendations on treating IGAS cases.
- To summarize preferred agents for IGAS chemoprophylaxis.
Main Methods:
- Review and update of existing Canadian guidelines for IGAS.
- Focus on chemoprophylaxis strategies for close contacts of IGAS patients.
- Discussion of antibiotic choices, including penicillin and clindamycin.
Main Results:
- Penicillin remains the primary treatment for group A streptococcal disease.
- Clindamycin's role in IGAS treatment is clarified.
- Preferred chemoprophylactic agents for IGAS contacts are summarized.
Conclusions:
- Updated guidance is essential due to rising IGAS rates in Canada.
- Clearer protocols for IGAS management and chemoprophylaxis are provided.
- This practice point aims to improve consistent application of guidelines across Canada.
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